Metgyl Tablet Drug Interactions

Alcohol: It is recommended that metronidazole not be used concurrently with ingestion of alcohol; may result in disulfiram-like effects.
Anticoagulants, coumarin or indandione-derivative: Effects may be potentiated when these agents are used concurrently with metronidazole, periodic prothrombin time determinations may be required to determine if dosage adjustments of anticoagulants are necessary.
Cimetidine: Hepatic metabolism of metronidazole may be decreased when metronidazole and cimetidine are used concurrently, possibly resulting in delayed elimination and increased serum metronidazole concentrations.
Disulfiram: It is recommended that metronidazole not be used concurrently with, or for 2 weeks following, disulfiram in alcoholic patients; such use may result in confusion and psychotic reactions.
Lithium: Lithium concentrations may increase when metronidazole therapy is introduced; serum lithium and serum creatinine levels should be monitored several days after beginning metronidazole in order to detect impending lithium intoxication.
Phenobarbital: Phenobarbital may induce microsomal liver enzymes, increasing metronidazole's metabolism and resulting in a decrease in half-life and plasma concentration.
Phenytoin: Metronidazole may impair the clearance of phenytoin, increasing phenytoin's plasma concentration.
Aspartate amino transferase assay: It may give spuriously low values in patients taking metronidazole depending on the method used.